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Role of trade-off between sexual and vertical routes for evolution of pathogen transmission
- 1.0446617 - BC 2016 RIV DE eng J - Journal Article
Bernhauerová, V. - Berec, Luděk
Role of trade-off between sexual and vertical routes for evolution of pathogen transmission.
Theoretical Ecology. Roč. 8, č. 1 (2015), s. 23-36. ISSN 1874-1738. E-ISSN 1874-1746
Grant - others:Masaryk University(CZ) MUNI/A/0849/2012
Institutional support: RVO:60077344
Keywords : adaptive dynamics * frequency-dependent transmission * infectious disease
Subject RIV: EH - Ecology, Behaviour
Impact factor: 2.085, year: 2015
http://link.springer.com/article/10.1007%2Fs12080-014-0234-8
Using an empirically suggested trade-off between the horizontal and vertical transmission modes, we develop and analyze a model to study evolutionary dynamics of sterilizing, sexually transmitted infections which can also be transmitted vertically. Assuming several flexible forms of the trade-off, our evolutionary analysis reveals a rich spectrum of evolutionary outcomes. In particular, evolution of pure sexual, pure vertical and mixed transmission is possible, in addition to a frequent occurrence of evolutionary suicide. These outcomes can also arise via evolutionary branching and be combined in several evolutionary bistability regimes. We also show that the shape of the trade-off between the two transmission modes significantly affects pathogen evolution; while vertical transmission dominates for concave and sigmoid trade-offs, sexual transmission is most commonly observed under convex trade-offs.
Permanent Link: http://hdl.handle.net/11104/0248587
Number of the records: 1