Number of the records: 1
A New Analogue of Locked Cyclohexane Nucleic Acids
- 1.0446581 - ÚOCHB 2016 RIV DE eng J - Journal Article
Šála, Michal - Dejmek, Milan - Procházková, Eliška - Hřebabecký, Hubert - Rybáček, Jiří - Dračínský, Martin - Novák, Pavel - Rosenbergová, Šárka - Rosenberg, Ivan - Nencka, Radim
A New Analogue of Locked Cyclohexane Nucleic Acids.
Synthesis. Roč. 47, č. 17 (2015), s. 2654-2662. ISSN 0039-7881. E-ISSN 1437-210X
R&D Projects: GA ČR GPP207/12/P625; GA ČR GA13-26526S
Institutional support: RVO:61388963
Keywords : nucleosides * bicyclic compounds * oligonucleotides * carbocycles * medicinal chemistry
Subject RIV: CC - Organic Chemistry
Impact factor: 2.652, year: 2015
We report on a new analogue of locked cyclohexane nucleic acids that contains an adenine nucleobase at an alternative position and which resembles homo-DNA. The crucial locked carbocyclic nucleoside monomer was prepared with high enantioselectivity and was subsequently incorporated into a pair of modified oligonucleotides that were subjected to hybridization studies.
Permanent Link: http://hdl.handle.net/11104/0248634
Number of the records: 1