Practical considerations for a hybrid liquid junction CE/MS interface

0445269 - ÚIACH 2016 CH eng A - Abstract
Foret, František - Křenková, Jana - Klepárník, Karel
Practical considerations for a hybrid liquid junction CE/MS interface.
HPLC 2015. Abstract Book. Geneve, 2015. s. 64-65. ISBN N.
[HPLC 2015. International Symposium on High Performance Liquid Phase Separations and Related Techniques /42./. 21.06.2015-25.06.2015, Geneva]
R&D Projects: GA ČR(CZ) GA14-06319S; GA ČR(CZ) GBP206/12/G014
Institutional support: RVO:68081715
Keywords : microfabrication * microfluidics * CE-ESI/MS
Subject RIV: CB - Analytical Chemistry, Separation

Capillary electrophoresis coupled to mass spectrometry (CE-MS) is gaining its space among the most powerful tools in modern (bio)analytical laboratory. The most challenging instrumental aspect in CE-MS is finding the balance between the stability and reproducibility of the signal and sensitivity of the analysis. Several interface designs have been developed in the past decade addressing the variety of instrumental aspects and ease of operation. Most of the interfaces can be categorized either into the sheath flow arrangement (considered to be a de facto standard), or sheathless design, often expected to provide the ultimate sensitivity. In this work we have explored a hybrid liquid junction based arrangement falling in between the sheath/sheathless designs and combining standard capillary columns with microfabricated parts.
Permanent Link: http://hdl.handle.net/11104/0247621