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Identification of large channels in cationic PEGylated cubosome nanoparticles by synchrotron radiation SAXS and Cryo-TEM imaging
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SYSNO ASEP 0443727 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Identification of large channels in cationic PEGylated cubosome nanoparticles by synchrotron radiation SAXS and Cryo-TEM imaging Author(s) Angelov, Borislav (UMCH-V) RID
Angelova, A. (FR)
Drechsler, M. (DE)
Garamus, V. M. (DE)
Mutafchieva, R. (BG)
Lesieur, S. (FR)Source Title Soft Matter - ISSN 1744-683X
Roč. 11, č. 18 (2015), s. 3686-3692Number of pages 7 s. Language eng - English Country GB - United Kingdom Keywords SAXS ; soft matter ; nanoparticles Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GAP208/10/1600 GA ČR - Czech Science Foundation (CSF) Institutional support UMCH-V - RVO:61389013 UT WOS 000353660000021 EID SCOPUS 84929493120 DOI 10.1039/C5SM00169B Annotation Extra-large nanochannel formation in the internal structure of cationic cubosome nanoparticles results from the interplay between charge repulsion and steric stabilization of the lipid membrane interfaces and is evidenced by cryogenic transmission electron microscopy (Cryo-TEM) and synchrotron radiation small-angle X-ray scattering (SAXS). The swollen cubic symmetry of the lipid nanoparticles emerges through a shaping transition of onion bilayer vesicle intermediates containing a fusogenic nonlamellar lipid. Cationic amphiphile cubosome particles, thanks to the advantages of their liquid crystalline soft porous nanoarchitecture and capability for multi-drug nanoencapsulation, appear to be of interest for the design of mitochondrial targeting devices in anti-cancer therapies and as siRNA nanocarriers for gene silencing. Workplace Institute of Macromolecular Chemistry Contact Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358 Year of Publishing 2016
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