Number of the records: 1
Lipid signaling in adipose tissue: Connecting inflammation & metabolism
- 1.
SYSNO ASEP 0443441 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lipid signaling in adipose tissue: Connecting inflammation & metabolism Author(s) Masoodi, M. (CH)
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Rossmeisl, Martin (FGU-C) RID, ORCID
Flachs, Pavel (FGU-C) RID
Kopecký, Jan (FGU-C) RID, ORCIDSource Title Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. - : Elsevier - ISSN 1388-1981
Roč. 1851, č. 4 (2015), s. 503-518Number of pages 16 s. Language eng - English Country NL - Netherlands Keywords adipocyte ; futile substrate cycle ; macrophage Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects GA13-00871S GA ČR - Czech Science Foundation (CSF) 7E12073 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) LH14040 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000350186800018 EID SCOPUS 84922569444 DOI https://doi.org/10.1016/j.bbalip.2014.09.023 Annotation Accumulation of immune cells, especially macrophages, and macrophage polarization from M2 to M1 state, affect intrinsic WAT signaling, namely anti-inflammatory and proinflammatory cytokines, fatty acids (FA), and lipid mediators derived from both n−6 and n−3 long-chain PUFA. Studies in mice suggest that (i) transient accumulation of M2 macrophages could be essential for the control of tissue FA levels during activation of lipolysis, (ii) currently unidentified M2 macrophage-borne signaling molecule(s) could inhibit lipolysis and re-esterification of lipolyzed FA back to triacylglycerols (TAG/FA cycle), and (iii) the egress of M2 macrophages from rebuilt WAT and removal of the negative feedback regulation could allow for a full unmasking of metabolic activities of adipocytes. Thus, M2 macrophages could support remodeling of WAT to a tissue containing metabolically flexible adipocytes endowed with a high capacity of both TAG/FA cycling and oxidative phosphorylation. This situation could be exemplified by a combined intervention using mild calorie restriction and dietary supplementation with EPA/DHA, which enhances the formation of “healthy” adipocytes Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2016
Number of the records: 1