0442656 - ÚEM 2015 RIV NL eng M - Monography Chapter
Morawski, M. - Filippov, M. - Tzinia, A. - Tsilibary, E. - Vargová, Lýdia
ECM in brain aging and dementia.
Brain Extracellular Matrix in Health and Disease. Amsterdam: ELSEVIER SCIENCE BV, 2014 - (Dityatev, A. - WehrleHaller, B. - Pitkanen, A.), s. 207-227. ISBN 978-0-444-63486-3
Institutional support: RVO:68378041
Keywords : Alzheimer's disease * extracellular space * perineuronal nets
Subject RIV: FH - Neurology

As the extracellular matrix (ECM) and matrix metalloproteinases (MMPs) are important regulators of plasticity, learning, and memory, age-related changes in the ECM composition are major determinants of the onset and development of the brain neurodegenerative disorders. The role of ECM has largely a dual “face” where beneficial and deleterious effects prevail depending on the actual state of the tissue and more study is necessary to understand the diverse roles of these molecules
Permanent Link: http://hdl.handle.net/11104/0245467