Oxidation of Protopine at a Pyrolytic Graphite Electrode Using Cyclic and Square-Wave Voltammetry

0440870 - BFÚ 2015 RIV DE eng J - Journal Article
Vrublová, E. - Ulrichová, J. - Šimánek, V. - Fojta, Miroslav - Vacek, J.
Oxidation of Protopine at a Pyrolytic Graphite Electrode Using Cyclic and Square-Wave Voltammetry.
Electroanalysis. Roč. 22, č. 24 (2010), s. 2879-2883. ISSN 1040-0397. E-ISSN 1521-4109
Institutional support: RVO:68081707
Keywords : Protopine * Isoquinoline alkaloids * Ex situ voltammetry
Subject RIV: BO - Biophysics
Impact factor: 2.721, year: 2010

This paper describes oxidation of the isoquinoline alkaloid, protopine (PR) at a pyrolytic graphite electrode (PGE) using cyclic and square-wave voltammetry. In the alkaline range (pH 7.5-10.5) of a Britton-Robinson (B-R) buffer, a PR oxidation can be observed as a well-developed voltammetric peak around +0.9 V (vs. Ag vertical bar AgCl vertical bar 3 M KCl). With increasing pH of the B-R buffer, the PR peak is shifted to less positive potentials. The acquired voltammetric data suggest that PR strongly adsorbs onto the surface of the pyrolytic graphite where it is subjected to irreversible electrochemical oxidation in its uncharged free (tricyclic) base form. The results are discussed in connection with the electrochemical oxidation of other isoquinoline alkaloids and the potential applications of these data.
Permanent Link: http://hdl.handle.net/11104/0243973