Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

Tan, A.S.; Dong, L.F.; Bezawork-Geleta, A.; Endaya, B.; Goodwin, J.; Bajziková, Martina; Kovářová, Jaromíra; Peterka, Martin; Yan, B.; Alizadeh Pesdar, E.; Sobol, Margaryta; Filimonenko, Anatolij; Stuart, S.; Vondrusová, Magdaléna; Klučková, Katarína; Sachaphibulkij, K.; Rohlena, Jakub; Hozák, Pavel; Truksa, Jaroslav; Eccles, D.; Haupt, D.; Griffiths, L.R.; Neužil, Jiří; Berridge, M.V.

doi:https://dx.doi.org/10.1016/j.cmet.2014.12.003

Number of the records: 1

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

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SYSNO ASEP	0440852
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA
Author(s)	Tan, A.S. (NZ) Dong, L.F. (AU) Bezawork-Geleta, A. (AU) Endaya, B. (AU) Goodwin, J. (AU) Bajziková, Martina (BTO-N)_RID Kovářová, Jaromíra (BTO-N)_RID Peterka, Martin (BTO-N) Yan, B. (AU) Alizadeh Pesdar, E. (AU) Sobol, Margaryta (UMG-J)_RID Filimonenko, Anatolij (UMG-J) Stuart, S. (AU) Vondrusová, Magdaléna (BTO-N)_RID Klučková, Katarína (BTO-N)_RID Sachaphibulkij, K. (AU) Rohlena, Jakub (BTO-N)_{RID, ORCID} Hozák, Pavel (UMG-J)_{RID, ORCID} Truksa, Jaroslav (BTO-N)_{RID, ORCID} Eccles, D. (AU) Haupt, D. (AU) Griffiths, L.R. (AU) Neužil, Jiří (BTO-N)_RID Berridge, M.V. (AU)
Source Title	Cell Metabolism. - : Cell Press - ISSN 1550-4131 Roč. 21, č. 1 (2015), s. 81-94
Number of pages	14 s.
Language	eng - English
Country	US - United States
Keywords	ELECTRON-TRANSPORT CHAIN ; MAMMALIAN MITOCHONDRIA ; TUNNELING NANOTUBES
Subject RIV	EB - Genetics ; Molecular Biology
R&D Projects	ED1.1.00/02.0109 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GAP301/10/1937 GA ČR - Czech Science Foundation (CSF)
	GA15-02203S GA ČR - Czech Science Foundation (CSF)
	GAP305/12/1708 GA ČR - Czech Science Foundation (CSF)
	GAP301/12/1851 GA ČR - Czech Science Foundation (CSF)
Institutional support	BTO-N - RVO:86652036 ; UMG-J - RVO:68378050
UT WOS	000347467900012
DOI	10.1016/j.cmet.2014.12.003
Annotation	We report that tumor cells without mitochondrial DNA (mtDNA) show delayed tumor growth, and that tumor formation is associated with acquisition of mtDNA from host cells. This leads to partial recovery of mitochondrial function in cells derived from primary tumors grown from cells without mtDNA and a shorter lag in tumor growth. Cell lines from circulating tumor cells showed further recovery of mitochondrial respiration and an intermediate lag to tumor growth, while cells from lung metastases exhibited full restoration of respiratory function and no lag in tumor growth. Stepwise assembly of mitochondrial respiratory (super)complexes was correlated with acquisition of respiratory function. Our findings indicate horizontal transfer of mtDNA from host cells in the tumor microenvironment to tumor cells with compromised respiratory function to re-establish respiration and tumor-initiating efficacy. These results suggest pathophysiological processes for overcoming mtDNA damage and support the notion of high plasticity of malignant cells.
Workplace	Institute of Biotechnology
Contact	Monika Kopřivová, Monika.Koprivova@ibt.cas.cz, Tel.: 325 873 700
Year of Publishing	2015

Number of the records: 1