0440592 - BFÚ 2015 RIV US eng J - Journal Article
Salazar, L. - Kashiwada, T. - Krejčí, Pavel - Meyer, A.N. - Casale, M. - Hallowell, M. - Wilcox, W. R. - Donoghue, D.J. - Thompson, L.M.
Fibroblast Growth Factor Receptor 3 Interacts with and Activates TGF beta-Activated Kinase 1 Tyrosine Phosphorylation and NFkB Signaling in Multiple Myeloma and Bladder Cancer.
PLoS ONE. Roč. 9, č. 1 (2014). ISSN 1932-6203. E-ISSN 1932-6203
Institutional support: RVO:68081707
Keywords : FACTOR-KAPPA-B * URINARY-BLADDER * DOWN-REGULATION
Subject RIV: BO - Biophysics
Impact factor: 3.234, year: 2014 ; AIS: 1.209, rok: 2014
DOI: https://doi.org/10.1371/journal.pone.0086470

Cancer is a major public health problem worldwide. In the United States alone, 1 in 4 deaths is due to cancer and for 2013 a total of 1,660,290 new cancer cases and 580,350 cancer-related deaths are projected. Comprehensive profiling of multiple cancer genomes has revealed a highly complex genetic landscape in which a large number of altered genes, varying from tumor to tumor, impact core biological pathways and processes. This has implications for therapeutic targeting of signaling networks in the development of treatments for specific cancers. The NF kappa B transcription factor is constitutively active in a number of hematologic and solid tumors, and many signaling pathways implicated in cancer are likely connected to NF kappa B activation. A critical mediator of NF kappa B activity is TGF beta-activated kinase 1 (TAK1). Here, we identify TAK1 as a novel interacting protein and target of fibroblast growth factor receptor 3 (FGFR3) tyrosine kinase activity.
Permanent Link: http://hdl.handle.net/11104/0243717