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Genes on B chromosomes: Old questions revisited with new tools
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SYSNO ASEP 0440518 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Genes on B chromosomes: Old questions revisited with new tools Author(s) Banaei-Moghaddam, A.M. (DE)
Martis, M.M. (DE)
Macas, Jiří (BC-A) RID, ORCID, SAI
Gundlach, H. (DE)
Himmelbach, A. (DE)
Altschmied, L. (DE)
Mayer, K. F. X. (DE)
Houben, A. (DE)Source Title Biochimica et Biophysica Acta-Gene Regulatory Mechanisms. - : Elsevier - ISSN 1874-9399
Roč. 1849, č. 1 (2015), s. 64-70Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords Gene regulation ; genome evolution ; junk DNA ; pseudogene ; transcription Subject RIV EB - Genetics ; Molecular Biology R&D Projects GBP501/12/G090 GA ČR - Czech Science Foundation (CSF) Institutional support BC-A - RVO:60077344 UT WOS 000348265300007 EID SCOPUS 84916918755 DOI https://doi.org/10.1016/j.bbagrm.2014.11.007 Annotation Background: B chromosomes are supernumerary dispensable parts of the karyotype which appear in some individuals of some populations in some species. Often, they have been considered as 'junk DNA' or genomic parasites without functional genes. Scope of review: Due to recent advances in sequencing technologies, it became possible to investigate their DNA composition, transcriptional activity and effects on the host transcriptome profile in detail. Here, we review the most recent findings regarding the gene content of B chromosomes and their transcriptional activities and discuss these findings in the context of comparable biological phenomena, like sex chromosomes, aneuploidy and pseudogenes. Major conclusions: Recent data suggest that B chromosomes carry transcriptionally active genic sequences which could affect the transcriptome profile of their host genome. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2016
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