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Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study
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SYSNO ASEP 0440505 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Indoor air pollution exposure from use of indoor stoves and fireplaces in association with breast cancer: a case-control study Author(s) White, A. J. (US)
Teitelbaum, S. L. (US)
Stellman, S. D. (US)
Beyea, J. (US)
Steck, S. E. (US)
Mordukhovich, I. (US)
McCarty, K. M. (US)
Ahn, J. (US)
Rössner ml., Pavel (UEM-P) RID, ORCID
Santella, R. M. (US)
Gammon, M. D. (US)Source Title Environmental Health: A Global Access Science Source
Roč. 13, Dec 12 (2014), s. 108Number of pages 12 s. Language eng - English Country GB - United Kingdom Keywords polycyclic aromatic hydrocarbons ; GST ; cancer Subject RIV DN - Health Impact of the Environment Quality Institutional support UEM-P - RVO:68378041 UT WOS 000348234600002 DOI 10.1186/1476-069X-13-108 Annotation The cells were treated for 24 h with B[a]P (1 μM, 10 μM, 25 μM) and EOMs (1 μg/ml, 10 μg/ml, 25 μg/ml). 25 μM of B[a]P and most of the tested doses of EOMs induced double strand breaks (DSBs) as indicated by H2AX phosphorylation. DNA damage was accompanied by induction of XRCC4 expression and an increased frequency of chromosomal aberrations. Translocations most frequently affected chromosome 7. We observed only a weak induction of Ku70/80 expression as well as ligation activity of nuclear extracts. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2015
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