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Effect of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, on behavioral and physiological parameters
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SYSNO ASEP 0437648 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effect of 7-nitroindazole, a neuronal nitric oxide synthase inhibitor, on behavioral and physiological parameters Author(s) Brožíčková, Carole (FGU-C)
Mikulecká, Anna (FGU-C) RID, ORCID
Otáhal, Jakub (FGU-C) RID, ORCID, SAISource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 63, č. 5 (2014), s. 637-648Number of pages 12 s. Language eng - English Country CZ - Czech Republic Keywords 7-nitroindazole ; open field test ; ladder rung walking test ; brain excitability ; blood gas analysis ; rat Subject RIV FH - Neurology R&D Projects GAP303/10/0999 GA ČR - Czech Science Foundation (CSF) GPP304/11/P386 GA ČR - Czech Science Foundation (CSF) GBP304/12/G069 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 CEZ AV0Z50110509 - FGU-C (2005-2011) UT WOS 000345590100014 EID SCOPUS 84919964090 Annotation Present study elucidate effect of an inhibitor of neuronal nitric oxide synthase on behavioral and physiological parameters. Our results show that in conscious rats 7-NI induces a rise in arterial blood pressure and significantly alters level of blood gases. 7-NI moreover affects locomotion and exploratory activity and induces walking incoordination and increases cortical excitability as revealed by electrophysiology Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2015
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