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Structural Basis of Polycomb Bodies
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SYSNO ASEP 0435953 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Structural Basis of Polycomb Bodies Author(s) Šmigová, J. (CZ)
Juda, P. (CZ)
Krejčí, Jana (BFU-R) RID, ORCID
Raška, I. (CZ)Number of authors 4 Source Title Folia Biologica. - : Univerzita Karlova v Praze - ISSN 0015-5500
Roč. 60, č. 1 (2014), s. 13-20Number of pages 8 s. Publication form Print - P Language eng - English Country CZ - Czech Republic Keywords Polycomb group proteins ; Polycomb body ; post-translational chromatin modifications Subject RIV BO - Biophysics R&D Projects GBP302/12/G157 GA ČR - Czech Science Foundation (CSF) EE2.3.30.0030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BFU-R - RVO:68081707 UT WOS 000343275800003 Annotation The spatial organization of the cell nucleus into separated domains with a specific macromolecular composition seems to be the fundamental principle that regulates its functioning. Because of the importance of regulation at the nuclear level, the cell nucleus and its domains have been intensively studied. This review is focused on the nuclear domain termed the Polycomb (PcG) body. We summarize and discuss data reported in the literature on different components of the PcG body that could form its structural basis. First, we describe the protein nature of the PcG body and the gene silencing factory model. Second, we review the target genes of Polycomb-mediated silencing and discuss their essentiality for the structural nature of the PcG body. In this respect, two different schematic models are presented. Third, we mention new data on the importance of RNAs, insulator elements and insulator proteins for the structure of PcG bodies. With this review, we hope to illustrate the importance of understanding the nature of the PcG subcompartment. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2015
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