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High level of Tregs is a positive prognostic marker in patients with HPV-positive oral and oropharyngeal squamous cell carcinomas
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SYSNO ASEP 0435694 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název High level of Tregs is a positive prognostic marker in patients with HPV-positive oral and oropharyngeal squamous cell carcinomas Tvůrce(i) Lukešová, E. (CZ)
Bouček, Jan (MBU-M)
Rotnáglová, E. (CZ)
Salaková, M. (CZ)
Koslabová, E. (CZ)
Grega, M. (CZ)
Eckschlager, T. (CZ)
Říhová, Blanka (MBU-M) RID
Procházka, B. (CZ)
Klozar, J. (CZ)
Tachezy, R. (CZ)Zdroj.dok. BioMed Research International. - : Hindawi - ISSN 2314-6133
Roč. 2014, APR 2014 (2014)Poč.str. 27 s. Jazyk dok. eng - angličtina Země vyd. US - Spojené státy americké Klíč. slova Human papillomavirus ; mRNA ; lymphocyte Vědní obor RIV EC - Imunologie Obor OECD Immunology CEP NT11542 GA MZd - Ministerstvo zdravotnictví Institucionální podpora MBU-M - RVO:61388971 UT WOS 000335233200001 DOI https://doi.org/10.1155/2014/303929 Anotace Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC). Patients with tumors of viral etiology have a lower recurrence rate and better prognosis. OPSCC is linked to an alteration in the immune system. Only a limited number of studies have correlated both the immunological parameters and HPV status with patient prognosis. The aim of this study was to determine whether HPV infection and the immunological status influence patient prognosis individually or in concurrence.Sixty patients with oral and oropharyngeal carcinomas were enrolled. They were divided into HPV-positive and HPV-negative groups based on the expression of HPV 16 E6 mRNA. Basic lymphocyte subpopulations were determined in the peripheral blood by means of flow cytometry. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2015
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