0434710 - ÚMG 2015 RIV US eng J - Journal Article
Pantzartzi, Chrysoula - Drosopoulou, E. - Scouras, Z.
Assessment and Reconstruction of Novel HSP90 Genes: Duplications, Gains and Losses in Fungal and Animal Lineages.
PLoS ONE. Roč. 8, č. 9 (2013), s. 1-11. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA MŠMT(CZ) ED1.1.00/02.0109
Institutional support: RVO:68378050
Keywords : Hsp90s * Fungi * duplication events
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.534, year: 2013 ; AIS: 1.37, rok: 2013
DOI: https://doi.org/10.1371/journal.pone.0073217

Hsp90s, members of the Heat Shock Protein class, protect the structure and function of proteins and play a significant task in cellular homeostasis and signal transduction. In order to determine the number of hsp90 gene copies and encoded proteins in fungal and animal lineages and through that key duplication events that this family has undergone, we collected and evaluated Hsp90 protein sequences and corresponding Expressed Sequence Tags and analyzed available genomes from various taxa. We provide evidence for duplication events affecting either single species or wider taxonomic groups. With regard to Fungi, duplicated genes have been detected in several lineages. In invertebrates, we demonstrate key duplication events in certain clades of Arthropoda and Mollusca, and a possible gene loss event in a hymenopteran family. Finally, we infer that the duplication event responsible for the two (a and b) isoforms in vertebrates occurred probably shortly after the split of Hyperoartia and Gnathostomata.
Permanent Link: http://hdl.handle.net/11104/0241982