0434397 - FGÚ 2015 RIV US eng J - Journal Article
Houdek, Pavel - Sumová, Alena
In Vivo Initiation of Clock Gene Expression Rhythmicity in Fetal Rat Suprachiasmatic Nuclei.
PLoS ONE. Roč. 9, č. 9 (2014), e107360. ISSN 1932-6203. E-ISSN 1932-6203
R&D Projects: GA ČR(CZ) GAP303/12/1108
Institutional support: RVO:67985823
Keywords : circadian * suprachiasmatic nuclei * ontogenesis * clock gene * entrainment * rat
Subject RIV: FH - Neurology
Impact factor: 3.234, year: 2014

Results of the study demonstrate that the circadian clock in the fetal rat suprachiasmatic nuclei develops gradually. At embryonic day 19 (E19), i.e., 4 days before delivery, the rhythms in expression of canonical clock genes Per2 and Bmal1 were absent and the clock developed just before birth. Expression of the clock gene Nr1d1 was rhythmic at E19 in absence of other clock gene expression rhythms and was thus likely driven by maternal cues instead of the core clockwork. The result suggest a molecular mechanism of how the rhythmic maternal cues entrain the developing fetal clock in the suprachiasmatic nuclei in vivo
Permanent Link: http://hdl.handle.net/11104/0238470