Age and activation determines the anticonvulsant effect of ifenprodil in rats

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SYSNO ASEP	0434262
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Age and activation determines the anticonvulsant effect of ifenprodil in rats
Author(s)	Mareš, Pavel (FGU-C)_{RID, ORCID}
Source Title	Naunyn-Schmiedeberg's Archives of Pharmacology. - : Springer - ISSN 0028-1298 Roč. 387, č. 8 (2014), s. 753-761
Number of pages	9 s.
Language	eng - English
Country	DE - Germany
Keywords	NMDA receptors ; NR2B subunit ; anticonvulsant action ; ontogeny ; rat
Subject RIV	FH - Neurology
R&D Projects	GBP304/12/G069 GA ČR - Czech Science Foundation (CSF)
Institutional support	FGU-C - RVO:67985823
UT WOS	000340589200005
EID SCOPUS	84904318340
DOI	10.1007/s00210-014-0987-z
Annotation	Ifenprodil is an antagonist of MDA receptors containing NR2B subunit. This subunit is dominant at early stages of brain development and therefore the anticonvulsant effect of this drug is marked in very young rats
Workplace	Institute of Physiology
Contact	Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400
Year of Publishing	2015

Number of the records: 1