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Changes in FGF21 Serum Concentrations and Liver mRNA Expression in an Experimental Model of Complete Lipodystrophy and Insulin-Resistant Diabetes
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SYSNO ASEP 0434081 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Changes in FGF21 Serum Concentrations and Liver mRNA Expression in an Experimental Model of Complete Lipodystrophy and Insulin-Resistant Diabetes Author(s) Špolcová, Andrea (UOCHB-X) RID, ORCID
Holubová, Martina (UOCHB-X) RID, ORCID
Mikulášková, Barbora (UOCHB-X)
Nagelová, Veronika (UOCHB-X) RID, ORCID
Štofková, A. (CZ)
Lacinová, Z. (CZ)
Jurčovičová, J. (CZ)
Haluzík, M. (CZ)
Maletínská, Lenka (UOCHB-X) RID, ORCID
Železná, Blanka (UOCHB-X) RID, ORCIDNumber of authors 10 Source Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 63, č. 4 (2014), s. 483-490Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords FGF21 ; A-ZIP mice ; lipodystrophy ; insulin resistance ; fatty liver ; GLUT-1 Subject RIV CE - Biochemistry R&D Projects GAP303/10/1368 GA ČR - Czech Science Foundation (CSF) GAP303/12/0576 GA ČR - Czech Science Foundation (CSF) Institutional support UOCHB-X - RVO:61388963 UT WOS 000342568400009 EID SCOPUS 84910053633 Annotation Patients with obesity and type 2 diabetes often display high levels of the anti-diabetic factor fibroblast growth factor-21 (FGF21), suggesting that the overproduction of FGF21 may result from increased adiposity in an attempt by white adipose tissue (WAT) to counteract insulin resistance. However, the production of FGF21 diabetes in the absence of WAT has not been examined. In this study, we investigated the effects of lipodystrophy in A-ZIP F-1 mice on FGF21 production in relation to diabetes. A-ZIP F-1 mice displayed high FGF21 plasma levels resulting from enhanced FGF21 mRNA expression in the liver. Concomitant enhancement of FGF21 receptor (FGFR1) and glucose transporter 1 (GLUT-1) mRNA expression was observed in the muscles of A-ZIP F-1 mice. Furthermore, the activation of hypothalamic NPY and AgRP mRNA expression positively correlated with plasma levels of FGF21 but not active ghrelin. Our study demonstrates that an increased FGF21 plasma level in lipodystrophic A-ZIP F-1 mice results mainly from up-regulated liver production but does not suffice to overcome the lipodystrophy-induced severe type 2-diabetes and insulin resistance in the liver linked to the augmented liver fat deposition. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2015
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