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Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression
- 1.0433446 - ÚEM 2015 RIV GB eng J - Journal Article
Nekvindová, J. - Contreras, J. A. - Juvan, P. - Tacer, K. F. - Anzenbacher, P. - Zídek, Zdeněk - Zapletalová, M. - Rozman, D. - Anzenbacherová, E.
Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression.
Xenobiotica. Roč. 44, č. 8 (2014), s. 708-715. ISSN 0049-8254. E-ISSN 1366-5928
Grant - others:GA MŠk(CZ) CZ.1.07/2.3.00/20.0019; GA MŠk(CZ) CZ.1.05/2.1.00/01.003
Institutional support: RVO:68378041
Keywords : induction * drug metabolism * antiviral
Subject RIV: FR - Pharmacology ; Medidal Chemistry
Impact factor: 2.199, year: 2014
Nucleotide analogues adefovir dipivoxil and tenofovir disoproxil are drugs used in the treatment of viral infections such as hepatitis B and AIDS, respectively. We have found no clinically significant effects of these drugs on the expression of cytochromes P450 genes. The data support the evidence of their safety with respect to drug-drug interactions.
Permanent Link: http://hdl.handle.net/11104/0237651
Number of the records: 1