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Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction
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SYSNO ASEP 0433305 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Effects of mtDNA in SHR-mtF344 versus SHR conplastic strains on reduced OXPHOS enzyme levels, insulin resistance, cardiac hypertrophy, and systolic dysfunction Author(s) Houštěk, Josef (FGU-C) RID, ORCID
Vrbacký, Marek (FGU-C) RID, ORCID
Hejzlarová, Kateřina (FGU-C)
Zídek, Václav (FGU-C) RID
Landa, Vladimír (FGU-C) RID
Šilhavý, Jan (FGU-C) RID, ORCID
Šimáková, Miroslava (FGU-C) RID, ORCID
Mlejnek, Petr (FGU-C) RID, ORCID
Kazdová, L. (CZ)
Mikšík, Ivan (FGU-C) RID, ORCID, SAI
Neckář, Jan (FGU-C) RID, ORCID
Papoušek, František (FGU-C)
Kolář, František (FGU-C) RID, ORCID, SAI
Kurtz, T. W. (US)
Pravenec, Michal (FGU-C) RID, ORCIDSource Title Physiological Genomics. - : American Physiological Society - ISSN 1094-8341
Roč. 46, č. 18 (2014), s. 671-678Number of pages 8 s. Language eng - English Country US - United States Keywords SHR conplastic strain with F344 mtDNA ; impaired glucose tolerance ; systolic dysfunction Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition R&D Projects LL1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GB14-36804G GA ČR - Czech Science Foundation (CSF) GA13-10267S GA ČR - Czech Science Foundation (CSF) 7E10067 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support FGU-C - RVO:67985823 UT WOS 000341705900001 EID SCOPUS 84907143245 DOI https://doi.org/10.1152/physiolgenomics.00069.2014 Annotation In the current study, we investigated the metabolic and hemodynamic effects of the SHR versus F344 mtDNA by comparing the SHR versus SHR-mtF344 conplastic strains that are genetically identical except for their mitochondrial genomes. Altogether 13 amino acid substitutions in protein coding genes, 7 single nucleotide polymorphisms in tRNA genes and 12 single nucleotide changes in rRNA genes were detected in F344 mtDNA when compared to SHR mtDNA. Analysis of oxidative phosphorylation system (OXPHOS) in heart left ventricles (LV), muscle and liver revealed reduced activity and content of several respiratory chain complexes in SHR-mtF344 conplastic rats when compared to the SHR strain. Lower function of OXPHOS in LV of conplastic rats was associated with significantly increased relative ventricular mass and reduced fractional shortening which was independent of blood pressure Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2015
Number of the records: 1