Number of the records: 1
Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma
- 1.0432084 - FGÚ 2015 RIV GR eng J - Journal Article
Olejár, Tomáš - Větvička, D. - Zadinová, M. - Poučková, P. - Kukal, J. - Ježek, Petr - Matěj, R.
Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma.
Anticancer Research. Roč. 34, č. 7 (2014), s. 3511-3515. ISSN 0250-7005. E-ISSN 1791-7530
R&D Projects: GA ČR(CZ) GAP302/10/0346
Institutional support: RVO:67985823
Keywords : PAR2 * melanoma * metastasis * murine model
Subject RIV: EA - Cell Biology
Impact factor: 1.826, year: 2014
Differences of metastatic spread of normal proteinase-activated receptor 2 (Par2+/+) melanoma B16 in Par2−/− (knock-out) animals compared with C57Bl6 mice were investigated. Excised primary tumors were in average larger in Par2−/− mice (360 mm3 vs. 221 mm3 in C57Bl6/J). Distant spontaneous metastases developed in only 3 of 9 of Par2−/− mice in comparison to 6 of 9 controls. Host Par2 melanoma model contributes to the limitation of local cancer progression in one area, while on the other hand is important for enhancing distant metastatic spread
Permanent Link: http://hdl.handle.net/11104/0236585
Number of the records: 1