0431253 - ÚEM 2015 RIV US eng J - Journal Article
Honsa, Pavel - Pivoňková, Helena - Harantová, Lenka - Butenko, Olena - Kriška, Ján - Džamba, Dávid - Rusňáková, Vendula - Valihrach, Lukáš - Kubista, Mikael - Anděrová, Miroslava
Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.
Glia. Roč. 62, č. 12 (2014), s. 2004-2021. ISSN 0894-1491. E-ISSN 1098-1136
R&D Projects: GA ČR GA13-02154S; GA ČR(CZ) GBP304/12/G069; GA MŠMT(CZ) ED1.1.00/02.0109
Grant - others:GA MŠk(CZ) CZ.1.07/2.3.00/30.0045
Institutional support: RVO:68378041 ; RVO:86652036
Keywords : Astrocytes * focal and global cerebral ischemia * HCN channels
Subject RIV: FH - Neurology
Impact factor: 6.031, year: 2014

The increased expression of HCN channels in reactive astrocytes was detected on mRNA and protein levels following ischemic injury and the presence of functional HCN channels and their modulation by cAMP and ZD7288 was revealed by patch-clamp technique. Our results demonstrate that regardless of the type of ischemic injury, reactive astrocytes express HCN channels, which could therefore be an important therapeutic target in post-stroke therapy.
Permanent Link: http://hdl.handle.net/11104/0239346