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Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast
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SYSNO ASEP 0430431 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Sphingolipid levels crucially modulate lateral microdomain organization of plasma membrane in living yeast Author(s) Večeř, J. (CZ)
Veselá, Petra (UEM-P) RID, ORCID
Malínský, Jan (UEM-P) RID, ORCID
Herman, P. (CZ)Number of authors 4 Source Title FEBS Letters. - : Wiley - ISSN 0014-5793
Roč. 588, č. 3 (2014), s. 443-449Number of pages 7 s. Language eng - English Country NL - Netherlands Keywords membrane microdomain ; lipid order ; fluidity Subject RIV BO - Biophysics R&D Projects GAP205/12/0720 GA ČR - Czech Science Foundation (CSF) Institutional support UEM-P - RVO:68378041 UT WOS 000329976800010 EID SCOPUS 84892791993 DOI 10.1016/j.febslet.2013.11.038 Annotation We found significantly reduced abundance of gel-like microdomains in the plasma membrane of living Saccharomyces cerevisiae cells with compromised biosynthesis of sphingolipids. The phenotype could be reverted by the supply of exogenous dihydrosphingosine. The data indicate that organization of lateral microdomains is an essential physiological role of sphingolipids. Workplace Institute of Experimental Medicine Contact Lenka Koželská, lenka.kozelska@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2015
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