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Crinane Alkaloids of the Amaryllidaceae with Cytotoxic Effects in Human Cervical Adenocarcinoma (HeLa) Cells
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SYSNO ASEP 0429594 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Crinane Alkaloids of the Amaryllidaceae with Cytotoxic Effects in Human Cervical Adenocarcinoma (HeLa) Cells Author(s) Nair, J. J. (ZA)
Rárová, L. (CZ)
Strnad, Miroslav (UEB-Q) RID, ORCID
Bastida, J. (ES)
Cheesman, L. (ZA)
van Staden, J. (ZA)Source Title Natural Product Communications - ISSN 1934-578X
Roč. 9, č. 4 (2014), s. 461-466Number of pages 6 s. Language eng - English Country US - United States Keywords Alkaloid ; Amaryllidaceae ; Apoptosis Subject RIV EB - Genetics ; Molecular Biology R&D Projects LO1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support UEB-Q - RVO:61389030 UT WOS 000335083500006 EID SCOPUS 84898799613 Annotation The family Amaryllidaceae has a long history of usage in the traditional medicinal practices of the indigenous peoples of South Africa, with three of its species known to be used for cancer treatment. Furthermore, the Amaryllidaceae is widely recognized for its unique alkaloid constituents, several of which exhibit potent and selective cytotoxic activities. In this study, several crinane alkaloids derived from local Amaryllidaceae species were examined for cytotoxic effects against the human cervical adenocarcinoma cell line, of which distichamine was the most potent (IC50 2.2 mu M). Workplace Institute of Experimental Botany Contact David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469 Year of Publishing 2015
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