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Nuclear Structures Surrounding Internal Lamin Invaginations
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SYSNO ASEP 0427969 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Nuclear Structures Surrounding Internal Lamin Invaginations Author(s) Legartová, Soňa (BFU-R) ORCID
Stixová, Lenka (BFU-R) RID, ORCID
Laur, O. (US)
Kozubek, Stanislav (BFU-R) RID
Sehnalová, Petra (BFU-R)
Bártová, Eva (BFU-R) ORCIDNumber of authors 6 Source Title Journal of Cellular Biochemistry. - : Wiley - ISSN 0730-2312
Roč. 115, č. 3 (2014), s. 476-487Number of pages 12 s. Publication form Print - P Language eng - English Country US - United States Keywords LAMINS ; NUCLEAR PORES ; CHROMATIN Subject RIV BO - Biophysics R&D Projects LD11020 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Institutional support BFU-R - RVO:68081707 UT WOS 000330906300007 DOI 10.1002/jcb.24681 Annotation A- and C-type lamins are intermediate filament proteins responsible for the maintenance of nuclear shape and most likely nuclear architecture. Here, we propose that pronounced invaginations of A/C-type lamins into the nuclear interior represent channels for the transport of regulatory molecules to and from nuclear and nucleolar regions. Using fluorescent protein technology and immunofluorescence, we show that A-type lamin channels interact with several nuclear components, including fibrillarin- and UBF-positive regions of nucleoli, foci of heterochromatin protein 1 , polycomb group bodies, and genomic regions associated with DNA repair. Similar associations were observed between A/C-type lamin channels and nuclear pores, lamin-associated protein LAP2, and promyelocytic leukemia nuclear bodies. Interestingly, regions with high levels of A/C-type lamins had low levels of B-type lamins, and vice versa. Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2015
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