Function of chromatin structure and dynamics in DNA damage, repair and misrepair: gamma-rays and protons in action

Ježková, L.; Falk, Martin; Falková, Iva; Davídková, Marie; Bačíková, Alena; Štefančíková, Lenka; Vachelová, Jana; Jelínek Michaelidesová, Anna; Lukášová, Emilie; Boreyko, A.; Krasavin, E.; Kozubek, Stanislav

doi:https://dx.doi.org/10.1016/j.apradiso.2013.01.022

Number of the records: 1

Function of chromatin structure and dynamics in DNA damage, repair and misrepair: gamma-rays and protons in action

1.

SYSNO ASEP	0424749
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Function of chromatin structure and dynamics in DNA damage, repair and misrepair: gamma-rays and protons in action
Author(s)	Ježková, L. (CZ) Falk, Martin (BFU-R)_{RID, ORCID} Falková, Iva (BFU-R)_ORCID Davídková, Marie (UJF-V)_{RID, ORCID, SAI} Bačíková, Alena (BFU-R) Štefančíková, Lenka (BFU-R) Vachelová, Jana (UJF-V)_{RID, SAI} Jelínek Michaelidesová, Anna (UJF-V)_{RID, ORCID, SAI} Lukášová, Emilie (BFU-R)_{RID, ORCID} Boreyko, A. (RU) Krasavin, E. (RU) Kozubek, Stanislav (BFU-R)_RID
Number of authors	12
Source Title	Applied Radiation and Isotopes. - : Elsevier - ISSN 0969-8043 Roč. 83, SI (2014), s. 128-136
Number of pages	9 s.
Publication form	Print - P
Language	eng - English
Country	GB - United Kingdom
Keywords	DNA double-strand breaks ; Higher-order chromatin structure and DSB repair ; Formation of chromosomal translocations
Subject RIV	BO - Biophysics
Subject RIV - cooperation	Nuclear Physics Institute - Biophysics
R&D Projects	EE2.3.30.0030 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GBP302/12/G157 GA ČR - Czech Science Foundation (CSF)
	GAP302/10/1022 GA ČR - Czech Science Foundation (CSF)
	GBP108/12/G108 GA ČR - Czech Science Foundation (CSF)
	LD12039 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	LD12008 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
Institutional support	BFU-R - RVO:68081707 ; UJF-V - RVO:61389005
UT WOS	000329539900012
DOI	10.1016/j.apradiso.2013.01.022
Annotation	According to their physical characteristics, protons and ion beams promise a revolution in cancer radiotherapy. Curing protocols however reflect rather the empirical knowledge than experimental data on DNA repair. This especially holds for the spatio-temporal organization of repair processes in the context of higher-order chromatin structure-the problematics addressed in this work. The consequences for the mechanism of chromosomal translocations are compared for gamma rays and proton beams. (C) 2013 Elsevier Ltd. All rights reserved.
Workplace	Institute of Biophysics
Contact	Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244
Year of Publishing	2014

Number of the records: 1