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Carborane-based carbonic anhydrase inhibitors
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SYSNO ASEP 0422652 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Carborane-based carbonic anhydrase inhibitors Author(s) Brynda, Jiří (UMG-J) RID
Mader, Pavel (UMG-J)
Šícha, Václav (UACH-T) RID, ORCID, SAI
Fábry, Milan (UMG-J) RID
Poncová, Kristýna (UOCHB-X)
Bakardjiev, Mario (UACH-T) SAI, RID
Grüner, Bohumír (UACH-T) RID, SAI, ORCID
Cígler, Petr (UOCHB-X) RID, ORCID
Řezáčová, Pavlína (UOCHB-X) RID, ORCIDSource Title Angewandte Chemie - International Edition. - : Wiley - ISSN 1433-7851
Roč. 52, č. 51 (2013), s. 13760-13763Number of pages 4 s. Language eng - English Country DE - Germany Keywords carbonic anhydrases ; carboranes ; drug discovery ; inhibitors ; structure elucidation Subject RIV EB - Genetics ; Molecular Biology R&D Projects TE01020028 GA TA ČR - Technology Agency of the Czech Republic (TA ČR) IAAX00320901 GA AV ČR - Academy of Sciences of the Czech Republic (AV ČR) Institutional support UMG-J - RVO:68378050 ; UOCHB-X - RVO:61388963 ; UACH-T - RVO:61388980 UT WOS 000328437200054 DOI 10.1002/anie.201307583 Annotation CA inhibitors: Human carbonic anhydrases (CAs) are diagnostic and therapeutic targets. Various carborane cages are shown to act as active-site-directed inhibitors, and substitution with a sulfamide group and other substituents leads to compounds with high selectivity towards the cancer-specific isozyme IX. Crystal structures of the carboranes in the active site provide information that can be applied to the structure-based design of specific inhibitors. Workplace Institute of Molecular Genetics Contact Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Year of Publishing 2014
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