0421688 - ÚPT 2014 RIV US eng J - Journal Article
Jiřík, Radovan - Nylund, K. - Gilja, O.H. - Mézl, M. - Harabis, V. - Kolář, R. - Standara, M. - Taxt, T.
Ultrasound Perfusion Analysis Combining Bolus-Tracking and Burst-Replenishment.
IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control. Roč. 60, č. 2 (2013), s. 310-319. ISSN 0885-3010. E-ISSN 1525-8955
R&D Projects: GA ČR GAP102/12/2380; GA MŠMT ED0017/01/01
Institutional support: RVO:68081731
Keywords : contrast-enhaced ultrasound * myocardial blood-flow * cerebral perfusion
Subject RIV: FS - Medical Facilities ; Equipment
Impact factor: 1.503, year: 2013 ; AIS: 0.513, rok: 2013
DOI: https://doi.org/10.1109/TUFFC.2013.2567

A new signal model and processing method for quantitative ultrasound perfusion analysis is presented, called bolus-and-burst. The method has the potential to provide absolute values of blood flow, blood volume, and mean transit time. Furthermore, it provides an estimate of the local arterial input function which characterizes the arterial tree, allowing accurate estimation of the bolus arrival time. The method combines two approaches to ultrasound perfusion analysis: bolus-tracking and burst-replenishment. A pharmacokinetic model based on the concept of arterial input functions and tissue residue functions is used to model both the bolus and replenishment parts of the recording. The pharmacokinetic model is fitted to the data using blind deconvolution. A preliminary assessment of the new perfusion-analysis method is presented on clinical recordings.
Permanent Link: http://hdl.handle.net/11104/0227974