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Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications
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SYSNO ASEP 0420861 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Synthesis of N-Substituted Piperidine Salts as Potential Muscarinic Ligands for Alzheimer's Applications Author(s) Boulos, J. (US)
Jakubík, Jan (FGU-C) RID, ORCID
Randáková, Alena (FGU-C) RID, ORCID
Avila, C. (US)Source Title Journal of Heterocyclic Chemistry - ISSN 0022-152X
Roč. 50, č. 6 (2013), s. 1363-1367Number of pages 5 s. Language eng - English Country US - United States Keywords N-piperidine substituted salts ; muscarinic receptor antagonists ; selectivity Subject RIV ED - Physiology R&D Projects GA305/09/0681 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000327293700018 EID SCOPUS 84888642341 DOI 10.1002/jhet.1742 Annotation Several heterocyclic N-piperidine substituted salts were synthesized that were found to inhibit the specific binding of the antagonists of muscarinic receptors. One of the compounds was found tobe 3 to 8 times more potent at M2 than other subtypes of muscarinic receptors in competition binding and selective for the M1 receptors over M3 and M5 in antagonizing accumulation of inositol phosphates induced by muscarinic agonist carbachol Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2014
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