Small-angle X-ray scattering and light scattering study of hybrid nanoparticles composed of thermoresponsive triblock copolymer F127 and thermoresponsive statistical polyoxazolines with hydrophobic moieties

Bogomolova, Anna; Hrubý, Martin; Pánek, Jiří; Rabyk, Mariia; Turner, S.; Bals, S.; Steinhart, Miloš; Zhigunov, Alexander; Sedláček, Ondřej; Štěpánek, Petr; Filippov, Sergey K.

doi:https://dx.doi.org/10.1107/S0021889813027064

Number of the records: 1

Small-angle X-ray scattering and light scattering study of hybrid nanoparticles composed of thermoresponsive triblock copolymer F127 and thermoresponsive statistical polyoxazolines with hydrophobic moieties

1.

SYSNO ASEP	0399157
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Small-angle X-ray scattering and light scattering study of hybrid nanoparticles composed of thermoresponsive triblock copolymer F127 and thermoresponsive statistical polyoxazolines with hydrophobic moieties
Author(s)	Bogomolova, Anna (UMCH-V)_RID Hrubý, Martin (UMCH-V)_{RID, ORCID} Pánek, Jiří (UMCH-V)_{RID, ORCID} Rabyk, Mariia (UMCH-V)_{RID, ORCID} Turner, S. (BE) Bals, S. (BE) Steinhart, Miloš (UMCH-V)_RID Zhigunov, Alexander (UMCH-V)_{RID, ORCID} Sedláček, Ondřej (UMCH-V)_{RID, ORCID} Štěpánek, Petr (UMCH-V)_{RID, ORCID} Filippov, Sergey K. (UMCH-V)_{RID, ORCID, SAI}
Source Title	Journal of Applied Crystallography. - : Wiley - ISSN 0021-8898 Roč. 46, č. 6 (2013), s. 1690-1698
Number of pages	9 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	F127 ; micelles ; SAXS
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	GAP108/12/0640 GA ČR - Czech Science Foundation (CSF)
Institutional support	UMCH-V - RVO:61389013
UT WOS	000327070000020
DOI	10.1107/S0021889813027064
Annotation	A combination of new thermoresponsive statistical polyoxazolines, poly[(2-butyl-2-oxazoline)-stat-(2-isopropyl-2-oxazoline)] [pBuOx-co-piPrOx], with different hydrophobic moieties and F127 surfactant as a template system for the creation of thermosensitive nanoparticles for radionuclide delivery has recently been tested [Pánek, Filippov, Hrubý, Rabyk, Bogomolova, Kucka & Stepánek (2012). Macromol. Rapid Commun. 33, 1683-1689]. It was shown that the presence of the thermosensitive F127 triblock copolymer in solution reduces nanoparticle size and polydispersity. This article focuses on a determination of the internal structure and solution properties of the nanoparticles in the temperature range from 288 to 312 K. Here, it is demonstrated that below the cloud point temperature (CPT) the polyoxazolines and F127 form complexes that co-exist in solution with single F127 molecules and large aggregates. When the temperature is raised above the CPT, nanoparticles composed of polyoxazolines and F127 are predominant in solution. These nanoparticles could be described by a spherical shell model. It was found that the molar weight and hydrophobicity of the polymer do not influence the size of the outer radius and only slightly change the inner radius of the nanoparticles. At the same time, molar weight and hydrophobicity did affect the process of nanoparticle formation. In conclusion, poly(2-oxazoline) molecules are fully incorporated inside of F127 micelles, and this result is very promising for the successful application of such systems in radionuclide delivery.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2014

Number of the records: 1