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The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance
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SYSNO ASEP 0396406 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance Author(s) Chmelař, Jindřich (BC-A)
Chung, K.-J. (DE)
Chavakis, T. (DE)Source Title Thrombosis and Haemostasis. - : Georg Thieme Verlag - ISSN 0340-6245
Roč. 109, č. 3 (2013), s. 399-406Number of pages 8 s. Publication form Print - P Language eng - English Country DE - Germany Keywords Obesity ; adipose tissue ; inflammation ; review ; leukocytes Subject RIV EC - Immunology Institutional support BC-A - RVO:60077344 UT WOS 000316164200007 DOI 10.1160/TH12-09-0703 Annotation Obesity is characterised by a chronic state of low-grade inflammation in different tissues including the vasculature. There is a causal link between adipose tissue (AT) inflammation and obesity-related metabolic complications, such as the development of insulin resistance and subsequently of type 2 diabetes. Intense efforts in the recent years have aimed at dissecting the pathophysiology of AT inflammation. The role of both innate and adaptive immune cells, such as macrophages or cytotoxic T cells in AT inflammation has been demonstrated. Besides these cells, more leukocyte subpopulations have been recently implicated in obesity, including neutrophils and eosinophils, mast cells, natural killer cells or dendritic cells. The involvement of multiple leukocyte subpopulations underlines the complexity of obesity-associated AT inflammation. In this review, we discuss the role of innate immune cells in AT inflammation, obesity and related metabolic disorders. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2014
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