Number of the records: 1
The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice
- 1.
SYSNO ASEP 0394829 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice Author(s) Hofer, Michal (BFU-R) RID, ORCID
Pospíšil, Milan (BFU-R)
Hoferová, Zuzana (BFU-R) RID
Komůrková, Denisa (BFU-R) RID, ORCID
Páral, P. (CZ)
Savvulidi, F. (CZ)
Šefc, L. (CZ)Number of authors 7 Source Title Purinergic Signalling - ISSN 1573-9538
Roč. 9, č. 2 (2013), s. 207-214Number of pages 8 s. Publication form Print - P Language eng - English Country NL - Netherlands Keywords ELEVATING EXTRACELLULAR ADENOSINE ; COLONY-STIMULATING FACTOR ; BONE-MARROW Subject RIV BO - Biophysics R&D Projects GA305/08/0158 GA ČR - Czech Science Foundation (CSF) GAP303/11/0128 GA ČR - Czech Science Foundation (CSF) OVBIOFYZ20101 GA MO - Ministry of Defence (MO) Institutional support BFU-R - RVO:68081707 UT WOS 000318559800008 DOI 10.1007/s11302-012-9340-5 Annotation This study continues our earlier findings on the hematopoiesis-modulating effects of adenosine A(1) and A(3) receptor agonists that were performed on committed hematopoietic progenitor and precursor cell populations. In the earlier experiments, N (6)-cyclopentyladenosine (CPA), an adenosine A(1) receptor agonist, was found to inhibit proliferation in the above-mentioned hematopoietic cell systems, whereas N (6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), an adenosine A(3) receptor agonist, was found to stimulate it. The topic of this study was to evaluate the possibility that the above-mentioned adenosine receptor agonists modulate the behavior of early hematopoietic progenitor cells and hematopoietic stem cells. Flow cytometric analysis of hematopoietic stem cells in mice was employed, as well as a functional test of hematopoietic stem and progenitor cells (HSPCs). Workplace Institute of Biophysics Contact Jana Poláková, polakova@ibp.cz, Tel.: 541 517 244 Year of Publishing 2014
Number of the records: 1