DNA-dependent protein kinase and its inhibition in support of radiotherapy

0394806 - BFÚ 2014 RIV GB eng J - Journal Article
Novotná, E. - Tichý, Adam - Pejchal, J. - Lukášová, Emilie - Salovská, B. - Vávrová, J.
DNA-dependent protein kinase and its inhibition in support of radiotherapy.
International Journal of Radiation Biology. Roč. 89, č. 6 (2013), s. 416-423. ISSN 0955-3002. E-ISSN 1362-3095
Institutional support: RVO:68081707
Keywords : DOUBLE-STRAND BREAK * CANCER-CELLS * REPAIR INHIBITION
Subject RIV: BO - Biophysics
Impact factor: 1.837, year: 2013

Purpose : Radiotherapy has been used as a treatment of almost 50% of all malignant tumors. The aim of this review is to provide a comprehensive overview of the recent knowledge in the field of molecular mechanisms of radiation-induced double-stranded breaks (DSB) repair. This paper gives particular emphasis to a key DNA repair enzyme, DNA-dependent protein kinase (DNA-PK), which plays a pivotal role in non-homologous end-joining. Furthermore, we discuss possibilities of DNA-PK inhibition and other molecular approaches employed in order to facilitate radiotherapy.
Permanent Link: http://hdl.handle.net/11104/0222969