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Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury
- 1.0392285 - FGÚ 2014 RIV GB eng J - Journal Article
Borchert, Gudrun H. - Hlaváčková, Markéta - Kolář, František
Pharmacological activation of mitochondrial BKCa channels protects isolated cardiomyocytes against simulated reperfusion-induced injury.
Experimental Biology and Medicine. Roč. 238, č. 2 (2013), s. 233-241. ISSN 1535-3702. E-ISSN 1535-3699
R&D Projects: GA AV ČR(CZ) IAA500110804; GA ČR(CZ) GAP303/12/1162
Institutional research plan: CEZ:AV0Z50110509
Institutional support: RVO:67985823
Keywords : potassium channels * cardiomyocytes * mitochondria * ischemia/reperfusion * cytoprotection * reactive oxygen species
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 2.226, year: 2013
The results indicate that pharmacological activation of mitochondrial large-conductance calcium-activated potassium channels effectively protects isolated cardiomyocytes against injury associated with simulated reperfusion. The mechanism of this form of protection requires signaling via reactive oxygen species, but not the activation of the pro-survival phosphatidylinositol-3-kinase pathway
Permanent Link: http://hdl.handle.net/11104/0221192
Number of the records: 1