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28th International Symposium on Shock Waves
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SYSNO ASEP 0386673 Document Type M - Monograph Chapter R&D Document Type Monograph Chapter Title Focused tandem shock waves in water and their potential application in cancer treatment Author(s) Lukeš, Petr (UFP-V) RID, ORCID
Šunka, Pavel (UFP-V) RID
Hoffer, Petr (UFP-V) RID
Stelmashuk, Vitaliy (UFP-V) RID
Beneš, J. (CZ)
Poučková, P. (CZ)
Zadinová, M. (CZ)
Zeman, J. (CZ)
Dibdiak, L. (CZ)
Kolářová, H. (CZ)
Tománková, K. (CZ)
Binder, S. (CZ)Source Title 28th International Symposium on Shock Waves, Part XXI: Special Session Medical and Biological Applications, 2. - Berlin Heidelberg : Springer Verlag GmbH, 2012 / Kontis K. - ISBN 978-3-642-25684-4 Pages s. 839-845 Number of pages 7 s. Number of copy 200 Number of pages 1121 Publication form Print - P Language eng - English Country DE - Germany Keywords focused shock waves ; underwater discharge ; cancer treatment Subject RIV BL - Plasma and Gas Discharge Physics R&D Projects GA202/09/1151 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z20430508 - UFP-V (2005-2011) DOI https://doi.org/10.1007/978-3-642-25685-1 Annotation Předneseno na: 28th International Symposium on Shock Waves, Manchester, GB, 17.07.-22.07.2011,str. 839-845: Physical principles of novel type of generator of focused tandem shock waves with time delay between the first and second shock waves of 10 µs have been presented. Generator produces at the focus strong shock wave with peak positive pressure up to 80 MPa followed by tensile wave with peak negative pressure down up to -80 MPa, generating thus at the focus a large number of cavitation. Biological effects of FTSW were demonstrated in vitro on hemolysis of erythrocytes and cell viability of acute lymphoblastic leukemia cells, and on tumor growth delay experiments ex vivo and in vivo. Synergetic cytotoxicity of FTSW with Photosan on tumor growth was observed, possibly due to cavitation induced sonodynamic effect of FTSW. Workplace Institute of Plasma Physics Contact Vladimíra Kebza, kebza@ipp.cas.cz, Tel.: 266 052 975 Year of Publishing 2013
Number of the records: 1