Self-assembled polymeric chelate nanoparticles as potential theranostic agents

Škodová, Michaela; Černoch, Peter; Štěpánek, Petr; Chánová, Eliška; Kučka, Jan; Kálalová, Zuzana; Kaňková, Dana; Hrubý, Martin

doi:https://dx.doi.org/10.1002/cphc.201200681

Number of the records: 1

Self-assembled polymeric chelate nanoparticles as potential theranostic agents

1.

SYSNO ASEP	0386090
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Self-assembled polymeric chelate nanoparticles as potential theranostic agents
Author(s)	Škodová, Michaela (UMCH-V)_RID Černoch, Peter (UMCH-V)_{RID, ORCID} Štěpánek, Petr (UMCH-V)_{RID, ORCID} Chánová, Eliška (UMCH-V)_RID Kučka, Jan (UMCH-V)_{RID, ORCID} Kálalová, Zuzana (UMCH-V) Kaňková, Dana (UMCH-V) Hrubý, Martin (UMCH-V)_{RID, ORCID}
Source Title	ChemPhysChem. - : Wiley - ISSN 1439-4235 Roč. 13, č. 18 (2012), s. 4244-4250
Number of pages	7 s.
Language	eng - English
Country	DE - Germany
Keywords	chelates ; nanoparticles ; polymers
Subject RIV	CD - Macromolecular Chemistry
R&D Projects	GPP207/10/P054 GA ČR - Czech Science Foundation (CSF)
	GA202/09/2078 GA ČR - Czech Science Foundation (CSF)
	GAP304/12/0950 GA ČR - Czech Science Foundation (CSF)
Institutional support	UMCH-V - RVO:61389013
CEZ	AV0Z40500505 - UMCH-V (2005-2011)
UT WOS	000313692600025
DOI	https://doi.org/10.1002/cphc.201200681
Annotation	Improvements in cancer diagnostics and therapy have recently attracted the interest of many different branches of science. This study presents one of the new possible approaches in the diagnostics and therapy of cancer by using polymeric chelates as carriers. Graft copolymers with a backbone containing 8-hydroxyquinoline-5-sulfonic acid chelating groups and poly(ethylene oxide) hydrophilic grafts are synthesized and characterized. The polymers assemble and form particles after the addition of a biometal cation, such as iron or copper. The obtained nanoparticles exhibit a hydrodynamic diameter of around 25 nm and a stability of at least several hours, which are counted as essential parameters for biomedical purposes. To prove their biodegradability, a model degradation with deferoxamine is performed and, together with high radiolabeling efficiency with copper-64, their possible use for nuclear medicine purposes is demonstrated.
Workplace	Institute of Macromolecular Chemistry
Contact	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Year of Publishing	2013

Number of the records: 1