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Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine
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SYSNO ASEP 0384593 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine Author(s) Brabcová, Jana (UOCHB-X) RID
Blažek, Jiří (UOCHB-X)
Janská, Lucie (UOCHB-X)
Krečmerová, Marcela (UOCHB-X) RID, ORCID
Zarevúcka, Marie (UOCHB-X) RIDNumber of authors 5 Source Title Molecules. - : MDPI - ISSN 1420-3049
Roč. 17, č. 12 (2012), s. 13813-13824Number of pages 12 s. Language eng - English Country CH - Switzerland Keywords lipase ; transesterification ; prodrug ; immobilization of enzymes Subject RIV CC - Organic Chemistry Institutional support UOCHB-X - RVO:61388963 UT WOS 000312608200009 DOI https://doi.org/10.3390/molecules171213813 Annotation Lipases from Geotrichum candidum 4013 (extracellular lipase and cell-bound lipase) were immobilized by adsorption on chitosan beads. The enzyme preparations were tested in the synthesis of ester prodrugs from racemic 9-(2,3-dihydroxypropyl)adenine in dimethylformamide with different vinyl esters (acetate, butyrate, decanoate, laurate, palmitate). The transesterification activities of these immobilized enzymes were compared with commercially available lipases (lipase from hog pancreas, Aspergillus niger, Candida antarctica, Pseudomonas fluorescens). Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2013
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