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Effect of hydrocarbon stapling on the properties of alpha-helical antimicrobial peptides isolated from the venom of hymenoptera

  1. 1.
    SYSNO ASEP0384565
    Document TypeJ - Journal Article
    R&D Document TypeJournal Article
    Subsidiary JČlánek ve WOS
    TitleEffect of hydrocarbon stapling on the properties of alpha-helical antimicrobial peptides isolated from the venom of hymenoptera
    Author(s) Chapuis, Hubert Jean (UOCHB-X)
    Slaninová, Jiřina (UOCHB-X)
    Bednárová, Lucie (UOCHB-X) RID, ORCID
    Monincová, Lenka (UOCHB-X)
    Buděšínský, Miloš (UOCHB-X) RID, ORCID
    Čeřovský, Václav (UOCHB-X) RID, ORCID
    Number of authors6
    Source TitleAmino Acids. - : Springer - ISSN 0939-4451
    Roč. 43, č. 5 (2012), s. 2047-2058
    Number of pages12 s.
    Languageeng - English
    CountryAT - Austria
    Keywordsantimicrobial peptides ; stapled peptides ; amphipathic helix ; CD spectroscopy
    Subject RIVCC - Organic Chemistry
    R&D ProjectsGA203/08/0536 GA ČR - Czech Science Foundation (CSF)
    CEZAV0Z40550506 - UOCHB-X (2005-2011)
    UT WOS000309863400022
    DOI https://doi.org/10.1007/s00726-012-1283-1
    AnnotationIntroducing all-hydrocarbon staples into short alpha-helical amphipathic antimicrobial peptides increases their hydrophobicity, hydrophobic moment, rigidity and generally alpha-helicity in water. Stapling generally makes the peptides more resistant to proteolytic degradation, particularly those that are doubly stapled. The introduction of olefinic amino acid residues and conformational restriction by stapling make the peptides significantly more hemolytic, and lead to a decrease of their antimicrobial potency against pathogenic bacteria. Unfortunately, the stapling of those peptides is not rendering compounds that would have better pharmacological qualities than the native unmodified potent peptides.
    WorkplaceInstitute of Organic Chemistry and Biochemistry
    Contactasep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
    Year of Publishing2013
Number of the records: 1  

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