Number of the records: 1
Developmental changes of the sensitivity of cardiac and liver mitochondrial permeability transition pore to calcium load and oxidative stress
- 1.
SYSNO ASEP 0383179 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Developmental changes of the sensitivity of cardiac and liver mitochondrial permeability transition pore to calcium load and oxidative stress Author(s) Drahota, Zdeněk (FGU-C) RID, ORCID
Milerová, Marie (FGU-C)
Endlicher, R. (CZ)
Rychtrmoc, D. (CZ)
Červinková, Z. (CZ)
Ošťádal, Bohuslav (FGU-C) RID, ORCIDSource Title Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 61, Suppl.1 (2012), S165-S172Number of pages 8 s. Language eng - English Country CZ - Czech Republic Keywords mitochondrial permeability transition pore ; cardiac mitochondria ; liver mitochondria ; oxidative stress ; calcium load ; rat Subject RIV ED - Physiology R&D Projects LL1204 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) GAP303/12/1162 GA ČR - Czech Science Foundation (CSF) Institutional support FGU-C - RVO:67985823 UT WOS 000307133700013 Annotation Opening of the mitochondrial membrane permeability transition pore (MPTP) is an important factor in the activation of apoptotic and necrotic processes in mammalian cells. In a previous paper we have shown that cardiac mitochondria from neonatal rats are more resistant to calcium load than mitochondria from adult animals. In this study we have analyzed the ontogenetic development of this parameter both in heart and in liver mitochondria. We found that the high resistance of heart mitochondria decreases from day 14 to adulthood. On the other hand, we did not observe a similar age-dependent sensitivity in liver mitochondria, particularly in the neonatal period. Some significant but relatively smaller increase could be observed only after day 30. When compared with liver mitochondria cardiac mitochondria were more resistant also to the peroxide activating effect on calcium-induced mitochondrial swelling. These data thus indicate that the MPTP of heart mitochondria is better protected against damaging effects of the calcium load and oxidative stress. We can only speculate that the lower sensitivity to calcium-induced swelling may be related to the higher ischemic tolerance of the neonatal heart Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2013
Number of the records: 1