0383049 - BC 2014 RIV US eng J - Journal Article
Bednářová, Andrea - Kodrík, Dalibor - Krishnan, N.
Unique roles od glucagon and glucagon-like peptides: Parallels in understanding the functions of adipokinetic hormones in stress responses in insects.
Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. Roč. 164, č. 1 (2013), s. 91-100. ISSN 1095-6433. E-ISSN 1531-4332
R&D Projects: GA ČR GAP501/10/1215
Grant - others:National Science Foundation, EPSCOR(US) MSU 012156-014
Institutional support: RVO:60077344
Keywords : adipokinetic hormone * glucagon * glucagon-like peptide
Subject RIV: ED - Physiology
Impact factor: 2.371, year: 2013 ; AIS: 0.656, rok: 2013
Result website:
http://www.sciencedirect.com/science/article/pii/S1095643312004904DOI: https://doi.org/10.1016/j.cbpa.2012.10.012

Glucagon is conventionally regarded as a hyperglycaemic hormone, which increases hepatic glucose output to the blood. Interestingly, glucagon-like peptides from the major fragment of proglucagon may also modulate response to stress in addition to their other physiological actions. These unique modes of action occur in response to stress situations and mirror the role of adipokinetic hormones (AKHs) in insects which perform a similar function. The findings on the anti-stress roles of glucagon and glucagon-like peptides in mammalian and non-mammalian vertebrates may throw light on the multiple stress responsive mechanisms which operate in a concerted manner under regulation by AKH in insects thus functioning as a stress responsive hormone.
Permanent Link: http://hdl.handle.net/11104/0217800