Number of the records: 1
HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction
- 1.0382635 - BFÚ 2013 RIV US eng J - Journal Article
Muselíková Polanská, Eva - Dobšáková, Zuzana - Dvořáčková, Martina - Fajkus, Jiří - Štros, Michal
HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction.
Chromosoma. Roč. 121, č. 4 (2012), s. 419-431. ISSN 0009-5915. E-ISSN 1432-0886
R&D Projects: GA ČR(CZ) GAP301/10/0590; GA ČR(CZ) GAP305/12/2475; GA AV ČR(CZ) IAA500040801
Institutional research plan: CEZ:AV0Z50040702
Keywords : HMGB1 protein * telomerase * mouse embryonic fibroblasts
Subject RIV: BO - Biophysics
Impact factor: 3.340, year: 2012
HMGB1 can modulate cellular activity of mammalian telomerase. Knockout of the HMGB1 gene in mouse embryonic fibroblasts results in chromosomal abnormalities, enhanced colocalization of gamma-H2AX foci at telomeres, and a moderate shortening of telomere lengths.
Permanent Link: http://hdl.handle.net/11104/0212802
Number of the records: 1