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Enzymatic Glycosylation of Small Molecules: Challenging Substrates Require Tailored Catalysts
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SYSNO ASEP 0381774 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Enzymatic Glycosylation of Small Molecules: Challenging Substrates Require Tailored Catalysts Author(s) Desmet, T. (BE)
Soetaert, W. (BE)
Bojarová, Pavla (MBU-M) ORCID
Křen, Vladimír (MBU-M) RID, ORCID
Dijkhuizen, L. (NL)
Eastwick-Field, V. (GB)
Schiller, A. (DE)Source Title Chemistry - A European Journal. - : Wiley - ISSN 0947-6539
Roč. 18, č. 35 (2012), s. 10786-10801Number of pages 16 s. Language eng - English Country DE - Germany Keywords acceptor specificity ; enzyme engineering ; glycosylation Subject RIV CE - Biochemistry Institutional support MBU-M - RVO:61388971 UT WOS 000307782800002 DOI https://doi.org/10.1002/chem.201103069 Annotation Glycosylation can significantly improve the physicochemical and biological properties of small molecules like vitamins, antibiotics, flavors, and fragrances. The chemical synthesis of glycosides is, however, far from trivial and involves multistep routes that generate lots of waste. In this review, biocatalytic alternatives are presented that offer both stricter specificities and higher yields. The advantages and disadvantages of different enzyme classes are discussed and illustrated with a number of recent examples. Progress in the field of enzyme engineering and screening are expected to result in new applications of biocatalytic glycosylation reactions in various industrial sectors Workplace Institute of Microbiology Contact Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Year of Publishing 2013
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