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Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles
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SYSNO ASEP 0380755 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Micronuclei in human peripheral blood lymphocytes exposed to mixed beams of X-rays and alpha particles Author(s) Staaf, E. (SE)
Brehwens, K. (SE)
Haghdoost, S. (SE)
Nievaart, S. (NL)
Pachnerová Brabcová, Kateřina (UJF-V) RID, ORCID, SAI
Czub, J. (PL)
Braziewicz, J. (PL)
Wojcik, A. (PL)Source Title Radiation and Environmental Biophysics - ISSN 0301-634X
Roč. 51, č. 3 (2012), s. 283-293Number of pages 11 s. Language eng - English Country DE - Germany Keywords Micronuclei ; LET ; Combined exposure ; Mixed beams ; Alpha particles ; X-rays Subject RIV BO - Biophysics CEZ AV0Z10480505 - UJF-V (2005-2011) UT WOS 000306694000006 DOI 10.1007/s00411-012-0417-x Annotation The purpose of this study was to analyse the cytogenetic effect of exposing human peripheral blood lymphocytes (PBL) to a mixed beam of alpha particles and X-rays. Whole blood collected from one donor was exposed to different doses of alpha particles (Am-241), X-rays and a combination of both. Micronuclei (MN) in binucleated PBL were scored as the endpoint. Moreover, the size of MN was measured. The results show that exposure of PBL to a mixed beam of high and low linear energy transfer radiation led to significantly higher than expected frequencies of MN. The measurement of MN size did not reveal any differences between the effect of alpha particles and mixed beam. In conclusion, a combined exposure of PBL to alpha particles and X-rays leads to a synergistic effect as measured by the frequency of MN. From the analysis of MN distributions, we conclude that the increase was due to an impaired repair of X-ray-induced DNA damage. Workplace Nuclear Physics Institute Contact Markéta Sommerová, sommerova@ujf.cas.cz, Tel.: 266 173 228 Year of Publishing 2013
Number of the records: 1