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Electronic and Vibrational Optical Activity of Several Peptides Related to Neurohypophyseal Hormones: Disulfide Group Conformation
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SYSNO ASEP 0380158 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Electronic and Vibrational Optical Activity of Several Peptides Related to Neurohypophyseal Hormones: Disulfide Group Conformation Author(s) Pazderková, Markéta (UOCHB-X) RID, ORCID
Bednárová, Lucie (UOCHB-X) RID, ORCID
Dlouhá, Helena (UOCHB-X)
Flegel, Martin (UOCHB-X)
Lebl, M. (CZ)
Hlaváček, Jan (UOCHB-X)
Setnička, V. (CZ)
Urbanová, M. (CZ)
Hynie, S. (CZ)
Klenerová, V. (CZ)
Baumruk, V. (CZ)
Maloň, Petr (UOCHB-X)Number of authors 12 Source Title Biopolymers - ISSN 0006-3525
Roč. 97, č. 11 (2012), s. 923-932Number of pages 10 s. Language eng - English Country US - United States Keywords neurohypophyseal hormones ; disulfide bridge ; Raman optical activity ; vibrational circular dichroism Subject RIV CF - Physical ; Theoretical Chemistry R&D Projects GAP205/10/1276 GA ČR - Czech Science Foundation (CSF) CEZ AV0Z40550506 - UOCHB-X (2005-2011) UT WOS 000307544800008 DOI https://doi.org/10.1002/bip.22105 Annotation Electronic and vibrational optical activity of the set of neurohypophyseal hormones and their analogs was investigated to clarify the S-S bond solution conformation. The selected compounds include oxytocin (I), lysine vasopressin (II), arginine vasopressin (III), and their analogs (IV-IX), differing widely in their pharmacological properties. We have extended the already known electronic circular dichroism data by new information provided by vibrational circular dichroism (VCD) and Raman optical activity (ROA). The use of VCD brought additional details on three-dimensional structure of the chain reversal in the ring moiety and on its left handedness. Furthermore, Raman scattering and ROA allowed us to deduce the sense of the disulfide bond torsion. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2013
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