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Evaluating chromosomal damage in workers exposed to hexavalent chromium and the modulating role of polymorphisms of DNA repair genes
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SYSNO ASEP 0379733 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Evaluating chromosomal damage in workers exposed to hexavalent chromium and the modulating role of polymorphisms of DNA repair genes Author(s) Halásová, E. (SK)
Mataková, T. (SK)
Mušák, L. (SK)
Poláková, Veronika (UEM-P) RID
Letková, L. (SK)
Dobrota, D. (SK)
Vodička, Pavel (UEM-P) RIDSource Title International Archives of Occupational and Environmental Health - ISSN 0340-0131
Roč. 85, č. 5 (2012), s. 473-481Number of pages 9 s. Language eng - English Country DE - Germany Keywords XPD Lys751Gln ; XPG Asn114His ; XPC Lys939Gln Subject RIV EB - Genetics ; Molecular Biology CEZ AV0Z50390703 - UEM-P (2007-2013) UT WOS 000305131300002 EID SCOPUS 84864280844 DOI https://doi.org/10.1007/s00420-011-0684-x Annotation Hexavalent chromium causes damage of DNA. We investigated 73 occupationally exposed workers and 71 control individuals for chromosomal aberrations as well as for tentative modulating role of polymorphisms in DNA repair genes on chromosomal damage with respect to the blood concentration of chromium. No apparent increase in chromosomal damage was recorded in chromium-exposed welders in comparison with controls, but genetic make-up in DNA repair genes may increase susceptibility toward averse efect of chromium. Workplace Institute of Experimental Medicine Contact Arzuv Čaryjeva, arzuv.caryjeva@iem.cas.cz, Tel.: 241 062 218, 296 442 218 Year of Publishing 2013
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