0379097 - MBÚ 2013 RIV DE eng J - Journal Article
Kolbaum, J. - Tartz, S. - Hartmann, W. - Helm, S. - Nagel, A. - Heussler, V. - Šebo, Peter - Fleischer, B. - Jacobs, T. - Breoler, M.
Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration.
European Journal of Immunology. Roč. 42, č. 4 (2012), s. 890-900. ISSN 0014-2980. E-ISSN 1521-4141
R&D Projects: GA ČR GA310/08/0447
Institutional research plan: CEZ:AV0Z50200510
Keywords : Immune modulation * Litomosoides sigmodontis * Plasmodium
Subject RIV: EE - Microbiology, Virology
Impact factor: 4.970, year: 2012 ; AIS: 1.97, rok: 2012
DOI: https://doi.org/10.1002/eji.201141955

Malaria is still responsible for up to 1 million deaths per year worldwide, highlighting the need for protective malaria vaccines. Helminth infections that are prevalent in malaria endemic areas can modulate immune responses of the host. Here we show that Strongy-Ioides ratti, a gut-dwelling nematode that causes transient infections, did not change the efficacy of vaccination against Plasmodium berghei. An ongoing infection with Litomosoides sigmodontis, a tissue-dwelling filaria that induces chronic infections in BALB/c mice, significantly interfered with vaccination efficacy. The induction of P. berghei circumspor-ozoite protein (CSP)-specific CD8+ T cells, achieved by a single immunization with a CSP fusion protein, was diminished in L. sigmodontis-infected mice
Permanent Link: http://hdl.handle.net/11104/0210368