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Microradiagraphy of biological samples with Timepix
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SYSNO ASEP 0379076 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Microradiagraphy of biological samples with Timepix Author(s) Dammer, J. (CZ)
Weyda, František (BC-A)
Beneš, J. (CZ)
Sopko, V. (CZ)
Jakůbek, J. (CZ)
Vondráček, V. (CZ)Number of authors 6 Source Title Journal of Instrumentation. - : Institute of Physics Publishing - ISSN 1748-0221
Roč. 6, C11005 (2011), s. 1-6Number of pages 6 s. Action International workshop on radiation imaging detectors /13./ Event date 03.07.2011-07.07.2011 VEvent location Zurich Country CH - Switzerland Event type WRD Language eng - English Country GB - United Kingdom Keywords X-ray detectors ; X-ray radiography and digital radiography (DR) ; pixelated detectors and associated VLSI electronics Subject RIV EA - Cell Biology R&D Projects 2B06005 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) CEZ AV0Z50070508 - ENTU-I, BC-A (2005-2011) UT WOS 000298320400005 DOI 10.1088/1748-0221/6/11/C11005 Annotation Microradiography is an imaging technique using X-rays in the study of internal structures of objects. This rapid and convenient imaging tool is based on differential X-ray attenuation by various tissues and structures within the biological sample. The non-absorbed radiation is detected with a suitable detector and creates a radiographic image. In order to detect the differential properties of X-rays passing through structures sample with different compositions, an adequate high-quality imaging detector is needed. We describe the recently developed radiographic apparatus, equipped with Timepix semiconductor pixel detector. The detector is used as an imager that counts individual photons of ionizing radiation, emitted by an X-ray tube FeinFocus with tungsten, copper or molybdenum anode. Thanks to the wide dynamic range, time over threshold mode-counter is used as Wilkinson type ADC allowing direct energy measurement in each pixel of Timepix detector and its high spatial resolution better than 1 m m, the setup is particularly suitable for radiographic imaging of small biological samples. We are able to visualize some internal biological processes and also to resolve the details of insects (morphology) using different anodes. These anodes generate different energy spectra. These spectra depend on the anode material. The resulting radiographic images varies according to the selected anode. Tiny live insects are an ideal object for our studies. Workplace Biology Centre (since 2006) Contact Dana Hypšová, eje@eje.cz, Tel.: 387 775 214 Year of Publishing 2013 Electronic address http://iopscience.iop.org/1748-0221/6/11/C11005/pdf/1748-0221_6_11_C11005.pdf
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