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Brain superoxide anion formation in immature rats during seizures: Protection by selected compounds
- 1.0376883 - FGÚ 2013 RIV US eng J - Journal Article
Folbergrová, Jaroslava - Otáhal, Jakub - Druga, Rastislav
Brain superoxide anion formation in immature rats during seizures: Protection by selected compounds.
Experimental Neurology. Roč. 233, č. 1 (2012), s. 421-429. ISSN 0014-4886. E-ISSN 1090-2430
R&D Projects: GA ČR GA309/08/0292; GA ČR GAP303/10/0999
Institutional research plan: CEZ:AV0Z50110509
Keywords : immature rats * DL-homocysteic acid-induced seizures * superoxide anion * SOD mimetics * protection * Fluoro-Jade B staining * brain damage
Subject RIV: FH - Neurology
Impact factor: 4.645, year: 2012
The present findings provide the evidence of oxidative stress in brain of immature rats during seizures induced by DL-homocysteic acid.The enhanced O-2 center dot(-)production was significantly attenuated or completely prevented by substances providing an anticonvulsant effect and by selected SOD mimetics.The increased O-2 center dot(-)generation precedes neuronal degeneration and may thus play a causative role in neuronal injury
Permanent Link: http://hdl.handle.net/11104/0209178
Number of the records: 1