Synthesis of novel azanorbornylpurine derivatives

Hřebabecký, Hubert; Dejmek, Milan; Dračínský, Martin; Šála, Michal; Leyssen, P.; Neyts, J.; Kaniaková, Martina; Krůšek, Jan; Nencka, Radim

doi:https://dx.doi.org/10.1016/j.tet.2011.11.035

Number of the records: 1

Synthesis of novel azanorbornylpurine derivatives

1.

SYSNO ASEP	0376064
Document Type	J - Journal Article
R&D Document Type	Journal Article
Subsidiary J	Článek ve WOS
Title	Synthesis of novel azanorbornylpurine derivatives
Author(s)	Hřebabecký, Hubert (UOCHB-X)_{RID, ORCID} Dejmek, Milan (UOCHB-X)_{RID, ORCID} Dračínský, Martin (UOCHB-X)_{RID, ORCID} Šála, Michal (UOCHB-X)_{RID, ORCID} Leyssen, P. (BE) Neyts, J. (BE) Kaniaková, Martina (FGU-C)_{RID, ORCID} Krůšek, Jan (FGU-C)_{RID, ORCID} Nencka, Radim (UOCHB-X)_{RID, ORCID}
Number of authors	9
Source Title	Tetrahedron. - : Elsevier - ISSN 0040-4020 Roč. 68, č. 4 (2012), s. 1286-1298
Number of pages	13 s.
Language	eng - English
Country	GB - United Kingdom
Keywords	azanorbornane ; purines ; coxsackievirus
Subject RIV	CC - Organic Chemistry
R&D Projects	1M0508 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
	GA202/09/0806 GA ČR - Czech Science Foundation (CSF)
	LC554 GA MŠMT - Ministry of Education, Youth and Sports (MEYS)
CEZ	AV0Z40550506 - UOCHB-X (2005-2011)
	AV0Z50110509 - FGU-C (2005-2011)
UT WOS	000300028800043
DOI	10.1016/j.tet.2011.11.035
Annotation	Novel racemic derivatives of 6-chloropurine, adenine, and 6-(cyclopropylamino)purine substituted with 2-azanorbornane, 7-azanorbornane, and 7-azabenzonorbornane were synthesized. All target compounds were tested for antiviral activity (CVB3, HCV) and 6-chloropurine derivatives were evaluated for potential activity as agonists of the neuronal and muscle nicotinic acetylcholine receptor.
Workplace	Institute of Organic Chemistry and Biochemistry
Contact	asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418
Year of Publishing	2013

Number of the records: 1