Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles

0373392 - BFÚ 2012 RIV US eng J - Journal Article
Najajreh, Y. - Ardeli-Tzaraf, Y. - Kašpárková, Jana - Heringová, Pavla - Prilutski, D. - Balter, L. - Jawbry, S. - Khazanov, E. - Perez, J.M. - Barenholz, Y. - Brabec, Viktor - Gibson, D.
Interactions of platinum complexes containing cationic, bicyclic, nonplanar piperidinopiperidine ligands with biological nucleophiles.
[Interakce komplexů platiny obsahujících kationtové, bicyklické, neplenární piperidinopiperidinové ligandy s biologickými nukleofilními látkami.]
Journal of Medicinal Chemistry. Roč. 49, č. 15 (2006), s. 4674-4683. ISSN 0022-2623. E-ISSN 1520-4804
R&D Projects: GA MŠMT(CZ) LC06030
Keywords : platinum complexes * piperidinopiperidine ligands * DNA
Subject RIV: BO - Biophysics
Impact factor: 5.115, year: 2006

The determination of the structures and DNA interactions and the reactions with GSH and ubiquitin of complexes of the general formula trans-[PtCl2(Am)(pip/pip].HCl, where pip/pip is 4-piperidinopiperidine and Am is NH3, methylamine, dimethylamine, n-propylamine, isopropylamine, n-butylamine, or cyclohexylamine were performed.

Byly popsány struktury, interakce s DNA a reakce s GSH a ubiquitinem komplexů obecného vzorce trans-[PtCl2(Am)(pip-pip)].HCl, kde pip-pip je 4-piperidinopiperidin a Am je NH3, methylamin, dimethylamin, n-propylamin, isopropylamin, n-butylamin nebo cyclohexylamin.
Permanent Link: http://hdl.handle.net/11104/0206501